RFX6
regulatory factor X, 6
Synonyms:
MTFS, RFXDC1, dJ955L16.1
Species:
Human RFX6 (222546), Mouse Rfx6 (320995), Rat Rfx6 (294395), Zebrafish rfx6 (556925), dog RFX6 (484096), domestic cat RFX6 (101096653), chicken RFX6 (421737), domestic guinea pig Rfx6 (100724529), naked mole-rat Rfx6 (101702134), cow RFX6 (524074)
UniProtKB ID:
Gene ID:
- Human(222546) Summary: The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]
- Mouse(320995) regulatory factor X, 6
- Rat(294395) regulatory factor X, 6
- Zebrafish(556925) regulatory factor X, 6
- dog(484096) regulatory factor X, 6
- domestic cat(101096653) regulatory factor X, 6
- chicken(421737) regulatory factor X, 6
- domestic guinea pig(100724529) regulatory factor X, 6
- naked mole-rat(101702134) regulatory factor X, 6
- cow(524074) regulatory factor X, 6
- sheep(101103984) regulatory factor X, 6
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