PTGIS
prostaglandin I2 (prostacyclin) synthase
Synonyms:
CYP8, CYP8A1, PGIS, PTGI
Species:
Human PTGIS (5740), Mouse Ptgis (19223), Rat Ptgis (25527), cow PTGIS (282021), sheep PTGIS (101116418), Goat PTGIS (100860894), naked mole-rat Ptgis (101700601), domestic guinea pig Ptgis (100734621), Zebrafish ptgis (559148), Horse PTGIS (100071412) ...More
UniProtKB ID:
Gene ID:
- Human(5740) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
- Mouse(19223) prostaglandin I2 (prostacyclin) synthase
- Rat(25527) prostaglandin I2 (prostacyclin) synthase
- cow(282021) prostaglandin I2 (prostacyclin) synthase
- sheep(101116418) prostaglandin I2 (prostacyclin) synthase
- Goat(100860894) prostaglandin I2 (prostacyclin) synthase
- naked mole-rat(101700601) prostaglandin I2 (prostacyclin) synthase
- domestic guinea pig(100734621) prostaglandin I2 (prostacyclin) synthase
- Zebrafish(559148) prostaglandin I2 (prostacyclin) synthase
- Horse(100071412) prostaglandin I2 (prostacyclin) synthase
- domestic cat(101082050) prostaglandin I2 (prostacyclin) synthase
- dog(485919) prostaglandin I2 (prostacyclin) synthase
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Small Molecule - Ligand
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