PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
Synonyms:
ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
Species:
Human PRKAR1A (5573), Mouse Prkar1a (19084), Rat Prkar1a (25725), chicken PRKAR1A (417438), dog PRKAR1A (480459), domestic cat PRKAR1A (101088632), cow PRKAR1A (615074), sheep PRKAR1A (100216463), domestic guinea pig Prkar1a (100729787), naked mole-rat Prkar1a (101722786)
UniProtKB ID:
Gene ID:
- Human(5573) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
- Mouse(19084) protein kinase, cAMP dependent regulatory, type I, alpha
- Rat(25725) protein kinase, cAMP-dependent, regulatory, type I, alpha
- chicken(417438) protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
- dog(480459) protein kinase, cAMP-dependent, regulatory, type I, alpha
- domestic cat(101088632) protein kinase, cAMP-dependent, regulatory, type I, alpha
- cow(615074) protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
- sheep(100216463) protein kinase, cAMP-dependent, regulatory, type I, alpha
- domestic guinea pig(100729787) protein kinase, cAMP-dependent, regulatory, type I, alpha
- naked mole-rat(101722786) protein kinase, cAMP-dependent, regulatory, type I, alpha
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Small Molecule - Inhibitor
Product Number
Description
Species
8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt, ≥97.0% (HPLC), powder,
Species
human