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Merck

NCOR2

nuclear receptor corepressor 2

Synonyms:
CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
Species:
UniProtKB ID:
Gene ID:
  • Human(9612) Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
  • Mouse(20602) nuclear receptor co-repressor 2
  • Rat(360801) nuclear receptor co-repressor 2
  • Zebrafish(561503) nuclear receptor co-repressor 2
  • chicken(416815) nuclear receptor corepressor 2
  • cow(538549) nuclear receptor corepressor 2
  • Horse(100059253) nuclear receptor corepressor 2
  • domestic cat(101083973) nuclear receptor corepressor 2
  • dog(486242) nuclear receptor corepressor 2
  • domestic guinea pig(100720194) nuclear receptor corepressor 2
  • naked mole-rat(101702626) nuclear receptor corepressor 2
  • sheep(101121042) nuclear receptor corepressor 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
ChIPAb+ SMRT - ChIP Validated Antibody and Primer Set, ascites fluid, from mouse,
Species Reactivity
human, mouse, rat
Application
ChIP
electrophoretic mobility shift assay

immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-SMRTe Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
ChIP
immunocytochemistry

western blot
Anti-SMRT Antibody, clone 1SM-1E7, ascites fluid, clone 1SM-1E7, from mouse,
Species Reactivity
human, mouse, rat
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NCOR2,
Species
human