MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Synonyms:
ACTFS, HDMX, hdm2
Species:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...More
UniProtKB ID:
Gene ID:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MDM2 Antibody, clone IF2, clone IF2, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-MDM2 Antibody, clone IF2, Alexa Fluor™ 488 Conjugate, clone IF2, from mouse, ALEXA FLUOR™ 488,
Species Reactivity
human
Application
immunocytochemistry
Anti-MDM2 (Ab-5) Mouse mAb (4B2C1.11), liquid, clone 4B2C1.11, Calbiochem®,
Species Reactivity
human
Application
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Species Reactivity
human
Application
Proteins
Product Number
Description
Species
MDM2, GST-tagged human, recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE),
Species
human