MCM6
minichromosome maintenance complex component 6
Synonyms:
MCG40308, Mis5, P105MCM
Species:
Human MCM6 (4175), Mouse Mcm6 (17219), Rat Mcm6 (29685), Zebrafish mcm6 (566409), cow MCM6 (517812), Thale Cress MCM6 (834492), domestic cat MCM6 (101092703), dog MCM6 (476131), chicken MCM6 (424295), fruit fly Mcm6 (31603) ...More
UniProtKB ID:
Gene ID:
- Human(4175) Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
- Mouse(17219) minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
- Rat(29685) minichromosome maintenance complex component 6
- Zebrafish(566409) MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)
- cow(517812) minichromosome maintenance complex component 6
- Thale Cress(834492) minichromosome maintenance protein 6
- domestic cat(101092703) minichromosome maintenance complex component 6
- dog(476131) minichromosome maintenance complex component 6
- chicken(424295) minichromosome maintenance complex component 6
- fruit fly(31603) Minichromosome maintenance 6
- sheep(101103786) minichromosome maintenance complex component 6
- Domestic Rabbit(100343390) minichromosome maintenance complex component 6
- naked mole-rat(101698140) minichromosome maintenance complex component 6
- domestic guinea pig(100731891) minichromosome maintenance complex component 6
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