MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Synonyms:
MARCH-I, RNF171
Species:
Human MARCH1 (55016), Mouse March1 (72925), Rat March1 (361135), chicken MARCH1 (422420), cow MARCH1 (617247), dog MARCH1 (612618), domestic cat MARCH1 (101098865), sheep MARCH1 (101106078), naked mole-rat March1 (101724772), domestic guinea pig March1 (100722498)
UniProtKB ID:
Gene ID:
- Human(55016) Summary: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]
- Mouse(72925) membrane-associated ring finger (C3HC4) 1
- Rat(361135) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- chicken(422420) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- cow(617247) membrane-associated ring finger (C3HC4) 1
- dog(612618) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- domestic cat(101098865) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- sheep(101106078) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- naked mole-rat(101724772) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
- domestic guinea pig(100722498) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
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