MAPK14
mitogen-activated protein kinase 14
Synonyms:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species:
Human MAPK14 (1432), Mouse Mapk14 (26416), Rat Mapk14 (81649), Domestic Rabbit MAPK14 (100341695), naked mole-rat Mapk14 (101715692), domestic guinea pig Mapk14 (100723285), sheep MAPK14 (100217411), chicken MAPK14 (421183), cow MAPK14 (534492), Horse MAPK14 (100063532) ...More
UniProtKB ID:
Gene ID:
- Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(26416) mitogen-activated protein kinase 14
- Rat(81649) mitogen activated protein kinase 14
- Domestic Rabbit(100341695) mitogen-activated protein kinase 14
- naked mole-rat(101715692) mitogen-activated protein kinase 14
- domestic guinea pig(100723285) mitogen-activated protein kinase 14
- sheep(100217411) mitogen-activated protein kinase 14
- chicken(421183) mitogen-activated protein kinase 14
- cow(534492) mitogen-activated protein kinase 14
- Horse(100063532) mitogen-activated protein kinase 14
- domestic cat(101101135) mitogen-activated protein kinase 14
- dog(403856) mitogen-activated protein kinase 14
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-p38α (Thr180/Tyr182) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2, clone 6E5.2, from mouse,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
western blot
Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal, culture supernatant, clone 8.78.8, from rabbit,
Species Reactivity
human, mouse, vertebrates
Application
immunofluorescence
western blot
western blot
PhosphoDetect Anti-p38 MAP Kinase (pThr¹⁸⁰, pTyr¹⁸²) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
canine, human, mouse, rat
Application
Anti-p38 MAPK Antibody, clone 2H9Q5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
Species
human
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
Species
human