LPHN1
latrophilin 1
Synonyms:
CIRL1, CL1, LEC2
Species:
Human LPHN1 (22859), Mouse Lphn1 (330814), Rat Lphn1 (65096), domestic cat LPHN1 (101091175), cow LPHN1 (788252), dog LPHN1 (610349), naked mole-rat Lphn1 (101708219), domestic guinea pig Lphn1 (100712781), sheep LPHN1 (101118356)
UniProtKB ID:
Gene ID:
- Human(22859) Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
- Mouse(330814) latrophilin 1
- Rat(65096) latrophilin 1
- domestic cat(101091175) latrophilin 1
- cow(788252) latrophilin 1
- dog(610349) latrophilin 1
- naked mole-rat(101708219) latrophilin 1
- domestic guinea pig(100712781) latrophilin 1
- sheep(101118356) latrophilin 1
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