LMNA
lamin A/C
Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species:
Human LMNA (4000), Mouse Lmna (16905), Rat Lmna (60374), Zebrafish lmna (195815), cow LMNA (404144), Horse LMNA (100057663), domestic cat LMNA (101086199), dog LMNA (480124), chicken LMNA (415464), domestic guinea pig Lmna (100735212) ...More
UniProtKB ID:
Gene ID:
- Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
- Mouse(16905) lamin A
- Rat(60374) lamin A/C
- Zebrafish(195815) lamin A
- cow(404144) lamin A/C
- Horse(100057663) lamin A/C
- domestic cat(101086199) lamin A/C
- dog(480124) lamin A/C
- chicken(415464) lamin A/C
- domestic guinea pig(100735212) lamin A/C
- naked mole-rat(101704567) lamin A/C
- sheep(101107924) lamin A/C
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Lamin A/C Antibody, clone 4C11, clone 4C11, from mouse,
Species Reactivity
syrian hamster, human, monkey, mouse, rat
Application
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-Lamin A/C Antibody, clone 14, clone 14, Upstate®, from mouse,
Species Reactivity
canine, chicken, human, mouse, rat
Application
immunocytochemistry
western blot
western blot
Anti-Phospho-Lamin A/C (Ser390), from rabbit,
Species Reactivity
human
Application
inhibition assay
western blot
western blot
Anti-Prelamin-A Antibody, clone 7G11, clone 7G11, from rat,
Species Reactivity
mouse
Application
immunofluorescence
western blot
western blot
Anti-Phospho Lamin A/C (Ser22), from rabbit,
Species Reactivity
human
Application
inhibition assay
western blot
western blot