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Merck

HDAC8

histone deacetylase 8

Synonyms:
CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species:
UniProtKB ID:
Gene ID:
  • Human(55869) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(70315) histone deacetylase 8
  • Rat(363481) histone deacetylase 8
  • Zebrafish(406740) histone deacetylase 8
  • cow(540666) histone deacetylase 8
  • domestic cat(101096383) histone deacetylase 8
  • dog(480957) histone deacetylase 8
  • chicken(422182) histone deacetylase 8
  • domestic guinea pig(100721893) histone deacetylase 8
  • naked mole-rat(101697998) histone deacetylase 8
  • sheep(101110121) histone deacetylase 8

Custom & Knockdown Gene Products

  • siRNA

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  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
[KO Validated]Anti-HDAC8 Antibody, clone 1O2Y5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-HDAC8 Antibody, serum, Upstate®,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Trichostatin A, ≥98% (HPLC), from Streptomyces sp.,
Species
human, mouse, rat
CI−994, ≥98% (HPLC), powder,
Species
human
Romidepsin, ≥98% (HPLC),
Species
human

Kits

Product Number
Description
Species
Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates,
Species
human, mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HDAC8,
Species
human
MISSION® esiRNA, targeting mouse Hdac8,
Species
mouse