GFRA2
GDNF family receptor alpha 2
Synonyms:
GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2
Species:
Human GFRA2 (2675), Mouse Gfra2 (14586), Rat Gfra2 (25136), chicken GFRA2 (395993), cow GFRA2 (514036), Horse GFRA2 (100146260), domestic cat GFRA2 (101091865), dog GFRA2 (609172), domestic guinea pig Gfra2 (100727079), naked mole-rat Gfra2 (101706123)
UniProtKB ID:
Gene ID:
- Human(2675) Summary: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Mouse(14586) glial cell line derived neurotrophic factor family receptor alpha 2
- Rat(25136) GDNF family receptor alpha 2
- chicken(395993) GDNF family receptor alpha 2
- cow(514036) GDNF family receptor alpha 2
- Horse(100146260) GDNF family receptor alpha 2
- domestic cat(101091865) GDNF family receptor alpha 2
- dog(609172) GDNF family receptor alpha 2
- domestic guinea pig(100727079) GDNF family receptor alpha 2
- naked mole-rat(101706123) GDNF family receptor alpha 2
- sheep(101119877) GDNF family receptor alpha 2
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