ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms:
ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Species:
Human ERBB3 (2065), Mouse Erbb3 (13867), Rat Erbb3 (29496), sheep ERBB3 (101103889), Domestic Rabbit ERBB3 (100008807), naked mole-rat Erbb3 (101721671), domestic guinea pig Erbb3 (100712946), chicken ERBB3 (693245), cow ERBB3 (785655), Horse ERBB3 (100059216) ...More
UniProtKB ID:
Gene ID:
- Human(2065) Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
- Mouse(13867) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Rat(29496) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- sheep(101103889) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Domestic Rabbit(100008807) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- naked mole-rat(101721671) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- domestic guinea pig(100712946) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- chicken(693245) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- cow(785655) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Horse(100059216) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- domestic cat(101085388) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- dog(481105) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2, clone RTJ2, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Phospho-ErbB3/HER3-Y1222 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-Erbb3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
Anti-erbB-3/HER-3 Antibody, clone 2F12, clone 2F12, Upstate®, from mouse,
Species Reactivity
bovine, human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-ErbB-3/HER3 Antibody, clone NG33, ,
Species Reactivity
human
Application
ELISA
flow cytometry
immunoprecipitation (IP)
flow cytometry
immunoprecipitation (IP)