DUT
deoxyuridine triphosphatase
Synonyms:
dUTPase
Species:
Human DUT (1854), Mouse Dut (110074), Rat Dut (497778), naked mole-rat Dut (101718828), domestic guinea pig Dut (100717103), sheep DUT (101110765), Zebrafish dut (449835), chicken DUT (769338), cow DUT (507945), domestic cat DUT (101099971)
UniProtKB ID:
Gene ID:
- Human(1854) Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
- Mouse(110074) deoxyuridine triphosphatase
- Rat(497778) deoxyuridine triphosphatase
- naked mole-rat(101718828) deoxyuridine triphosphatase
- domestic guinea pig(100717103) deoxyuridine triphosphatase
- sheep(101110765) deoxyuridine triphosphatase
- Zebrafish(449835) dUTP pyrophosphatase
- chicken(769338) deoxyuridine triphosphatase
- cow(507945) deoxyuridine triphosphatase
- domestic cat(101099971) deoxyuridine triphosphatase
- dog(609526) deoxyuridine triphosphatase
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