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Merck

DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

Synonyms:
Species:
Human DNMT3L (29947), Mouse Dnmt3l (54427), Rat Dnmt3l (309680), domestic guinea pig Dnmt3l (100729608), naked mole-rat Dnmt3l (101719207), sheep DNMT3L (101102451), dog DNMT3L (608536), domestic cat DNMT3L (101091300), cow DNMT3L (613785), Horse DNMT3L (100050680)
UniProtKB ID:
Q9UJW3, E9PB42, Q9BUJ4
Gene ID:
  • Human(29947) Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
  • Mouse(54427) DNA (cytosine-5-)-methyltransferase 3-like
  • Rat(309680) DNA (cytosine-5-)-methyltransferase 3-like
  • domestic guinea pig(100729608) DNA (cytosine-5-)-methyltransferase 3-like
  • naked mole-rat(101719207) DNA (cytosine-5-)-methyltransferase 3-like
  • sheep(101102451) DNA (cytosine-5-)-methyltransferase 3-like
  • dog(608536) DNA (cytosine-5-)-methyltransferase 3-like
  • domestic cat(101091300) DNA (cytosine-5-)-methyltransferase 3-like
  • cow(613785) DNA (cytosine-5-)-methyltransferase 3-like
  • Horse(100050680) DNA (cytosine-5-)-methyltransferase 3-like

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
ABE2910
Anti-DNMT3L, from rabbit,
Species Reactivity
mouse
Application
immunocytochemistry
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
EMU022701
MISSION® esiRNA, targeting mouse Dnmt3l,
Species
mouse