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Merck

CHAT

choline O-acetyltransferase

Synonyms:
CHOACTASE, CMS1A, CMS1A2
Species:
UniProtKB ID:
Gene ID:
  • Human(1103) Summary: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
  • Mouse(12647) choline acetyltransferase
  • Rat(290567) choline O-acetyltransferase
  • Zebrafish(100170938) choline acetyltransferase
  • cow(524732) choline O-acetyltransferase
  • domestic cat(751512) choline O-acetyltransferase
  • dog(486775) choline O-acetyltransferase
  • chicken(395314) choline O-acetyltransferase
  • Thale Cress(821249) acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase
  • naked mole-rat(101711939) choline O-acetyltransferase
  • domestic guinea pig(100718930) choline O-acetyltransferase
  • sheep(101117817) choline O-acetyltransferase

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CHAT antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Choline Acetyltransferase Antibody, Chemicon®, from chicken,
Species Reactivity
mouse
Application
immunocytochemistry
immunohistochemistry
Anti-Choline Acetyltransferase (ChAT) Antibody, clone 2K16, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Choline Acetyltransferase Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
immunohistochemistry
Anti-Choline Acetyltransferase Antibody, serum, Chemicon®,
Species Reactivity
guinea pig, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Cofactor

Product Number
Description
Species
Acetyl coenzyme A lithium salt, ≥93% (HPLC),
Species
human, mouse, rat
Acetyl coenzyme A trisodium salt, ≥93% (HPLC), powder,
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CHAT,
Species
human
MISSION® esiRNA, targeting mouse Chat,
Species
mouse