CACNB4
calcium channel, voltage-dependent, beta 4 subunit
Synonyms:
CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6
Species:
Human CACNB4 (785), Mouse Cacnb4 (12298), Rat Cacnb4 (58942), chicken CACNB4 (374259), domestic cat CACNB4 (101101576), cow CACNB4 (282161), Horse CACNB4 (100057916), dog CACNB4 (609361), sheep CACNB4 (101117907), domestic guinea pig Cacnb4 (100723776)
UniProtKB ID:
Gene ID:
- Human(785) Summary: This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- Mouse(12298) calcium channel, voltage-dependent, beta 4 subunit
- Rat(58942) calcium channel, voltage-dependent, beta 4 subunit
- chicken(374259) calcium channel, voltage-dependent, beta 4 subunit
- domestic cat(101101576) calcium channel, voltage-dependent, beta 4 subunit
- cow(282161) calcium channel, voltage-dependent, beta 4 subunit
- Horse(100057916) calcium channel, voltage-dependent, beta 4 subunit
- dog(609361) calcium channel, voltage-dependent, beta 4 subunit
- sheep(101117907) calcium channel, voltage-dependent, beta 4 subunit
- domestic guinea pig(100723776) calcium channel, voltage-dependent, beta 4 subunit
- naked mole-rat(101723713) calcium channel, voltage-dependent, beta 4 subunit
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